Publication Date

2014-07-29

Availability

Open access

Embargo Period

2014-07-29

Degree Type

Dissertation

Degree Name

Doctor of Philosophy (PHD)

Department

Kinesiology and Sport Sciences (Education)

Date of Defense

2014-06-25

First Committee Member

Kevin A. Jacobs

Second Committee Member

Arlette Perry

Third Committee Member

Joseph Signorile

Fourth Committee Member

John E. Lewis

Abstract

The Human Immunodeficiency Virus (HIV) pandemic remains a top national health priority. Chronic inflammation may be a critical component in the disease course of HIV as C-reactive protein (CRP) is elevated and associated with increased mortality. This study examined the effect of three months of combined aerobic and resistance exercise training among a diverse cohort of HIV-infected men and women. The fixed effect of time for CRP was found to be non-significant (F[1,57.3]=1.7, p=0.19). There was a significant fixed effect for time for upper body (F[1,51.6]=18.1, p<0.05) and lower body strength (F[1,48.0]=15.7, p<0.05) and significant declines in diastolic blood pressure (p=0.002) and waist circumference (p=0.027). Though levels of CRP were not impacted after three months training, participants demonstrated a significant increase in muscular strength as well as beneficial changes in metabolic risk factors. Future studies should focus on determining the optimal exercise intervention length and mode to reduce inflammation.

Keywords

Human Immunodeficiency Virus; Aerobic Exercise; Resistance Training; C-reactive Protein; Inflammation; Metabolic Risk

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