Publication Date
2016-09-20
Availability
Open access
Embargo Period
2016-09-19
Degree Type
Dissertation
Degree Name
Doctor of Philosophy (PHD)
Department
Biochemistry and Molecular Biology (Medicine)
Date of Defense
2016-08-16
First Committee Member
Richard Jope
Second Committee Member
Eleonore Beurel
Third Committee Member
Arthur Zelent
Fourth Committee Member
Mohammad Faghihi
Fifth Committee Member
Shaun Brothers
Abstract
Herein are described two novel outcomes, the up-regulation of 5HTR2C cluster miRNAs and IGF2, as a result of GSK3 inhibition by an antidepressant dose of ketamine that may contribute to the behavioral responses to ketamine.
Keywords
Depression; Glycogen Synthase Kinase-3; Ketamine; Hippocampus, microRNA; Insulin-Like Growth Factor 2
Recommended Citation
Grieco, Steven, "Antidepressant and Molecular Responses to Ketamine Linked to its Inhibition of Glycogen Synthase Kinase-3 (GSK3)" (2016). Open Access Dissertations. 1737.
http://scholarlyrepository.miami.edu/oa_dissertations/1737