Publication Date

2016-09-20

Availability

Open access

Embargo Period

2016-09-19

Degree Type

Dissertation

Degree Name

Doctor of Philosophy (PHD)

Department

Biochemistry and Molecular Biology (Medicine)

Date of Defense

2016-08-16

First Committee Member

Richard Jope

Second Committee Member

Eleonore Beurel

Third Committee Member

Arthur Zelent

Fourth Committee Member

Mohammad Faghihi

Fifth Committee Member

Shaun Brothers

Abstract

Herein are described two novel outcomes, the up-regulation of 5HTR2C cluster miRNAs and IGF2, as a result of GSK3 inhibition by an antidepressant dose of ketamine that may contribute to the behavioral responses to ketamine.

Keywords

Depression; Glycogen Synthase Kinase-3; Ketamine; Hippocampus, microRNA; Insulin-Like Growth Factor 2

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