Master of Science (MS)
Biochemistry and Molecular Biology (Medicine)
Date of Defense
First Committee Member
Dr. Walter Scott - Committee Member
Second Committee Member
Dr. Terace Fletcher - Committee Member
Third Committee Member
Dr. Jennifer Hu - Mentor
Dietary factors have been implicated in the risk of head and neck squamous cell carcinoma (HNSCC). Much interest has been placed upon the effects of suspected chemopreventative agents found in fruit and vegetables associated with low HNSCC risk. However, studies investigating specific uptake of these agents have failed to show positive results. The possibility exists that single chemopreventative agents fail to provide the same beneficial effect as the various compounds found in a fruits and vegetables is examined. Curatively treated head and neck squamous cell carcinoma patients ingested Juice Plus, a F&V extract supplement containing multiple chemopreventative agents, for 12 weeks. Lymphocyte samples of participants were collect pre- and post- treatment and examined in pairs. Despite the study currently still blinded, surrogate endpoint biomarkers were evaluated to observer any modification between pre- and post treatment samples. Although a paired t-test showed no significant difference between pre- and post treatment samples on surrogate endpoint biomarkers, there is a significant difference in population distribution between treatment times signifying a modification of the surrogate endpoint biomarkers. The exact nature of this difference is pending due to the blinded status of the study.
Alkaline Comet Assay; Cell Cycle Delay; Lymphocytes
Munoz, Daniel, "The Effects of Fruit and Vegetable Extracts on Surrogate Endpoint Biomarkers in Curatively Treated Head and Neck Squamous Cell Carcinoma Patients" (2009). Open Access Theses. 186.