Publication Date

2012-04-20

Availability

Open access

Embargo Period

2012-04-20

Degree Name

Master of Science (MS)

Department

Electrical and Computer Engineering (Engineering)

Date of Defense

2012-04-06

First Committee Member

Mohamed Abdel-Mottaleb

Second Committee Member

Fatta Basil Nahab

Third Committee Member

Saman Aliari Zonouz

Abstract

Essential Tremor (ET) is the most common neurological movement disorder, with slowly progressive symptoms that impact the patient's quality of life and ability to perform activities of daily living. Tremors in ET occur during kinetic, with two subtypes: postural tremors and kinetic tremors. Postural tremors appear when the arms are topically maintained in a position against gravity, whereas kinetic tremors appear during sustained voluntary movements such as writing or drawing. The underlying mechanisms of either tremor type are not known, and further work is needed to determine whether they are two manifestations of the same brain dysfunction, or consequences of different underlying causes. To further understand these disease manifestations, we employed functional magnetic resonance imaging (fMRI) in conjunction with quantitative tremor measures (accelerometry and spirography).

Keywords

Accelerometry; Essential Tremor; Functional MRI; Spirography

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