Predictors of progression to AIDS and AIDS-related death among HIV infected women

Date of Award




Degree Name

Doctor of Philosophy (Ph.D.)



First Committee Member

Theresa Gesse - Committee Chair


The purpose of this study was to examine the medical records of a cohort of HIV positive women to identify predictors of disease progression to AIDS or AIDS related death. Selected demographic, behavioral and clinical factors known to be associated with HIV disease progression were evaluated. Data were abstracted from the medical records of 114 HIV infected women who were followed longitudinally for up to 12 years. Descriptive statistics were generated for all variables and Chi square tests were used for analysis of categorical variables. The statistical techniques used to test the aims and hypotheses for this study included: simple and multiple logistical regression analyses, Kaplan-Meier survival analyses, and the Cox proportional-hazards regression model to compare the two groups with respect to time to AIDS or AIDS related death. It was concluded that there were no demographic or behavioral factors associated with disease progression in this cohort. Clinical factors significantly associated with disease progression included CDC classification at entry, the use of the antiretroviral medication Zidovudine, and two or more pregnancies. Nursing implications of this study and recommendations for further study are discussed.


Health Sciences, Nursing; Health Sciences, Public Health

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