Cognitive and developmental evaluation of perinatal HIV-1 infection during infancy

Date of Award




Degree Name

Doctor of Philosophy (Ph.D.)



First Committee Member

Keith G. Scott, Committee Chair


The relationship between pediatric Human Immunodeficiency Virus Type 1 (HIV-1) infection and cognitive and developmental functioning during infancy remains unclear. Issues such as mode of infection, prenatal drug abuse, timing of CNS disease, study design and test validity are often unaddressed. Therefore, fifty infants born to HIV-infected mothers without evidence of prenatal drug abuse were enrolled in a prospective descriptive study of perinatal HIV infection. Infants who developed AIDS were impaired on measures of visual memory, mental and motor development, and neurological functioning relative to non-infected comparisons. Developmental disabilities were observed in fifty percent of infants who developed AIDS, and were expressed as either specific cognitive deficits of visual memory, as measured by the Fagan Test of Infant Intelligence, or motor deficits, as measured by the Bayley Scales of Infant Development and neurological findings. The clinical implications of these findings upon knowledge of the neuropsychology of pediatric AIDS and brain-behavior relationships are discussed.


Psychology, Developmental; Psychology, Clinical; Health Sciences, Immunology

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