Health-related quality of life in children with HIV/AIDS

Date of Award




Degree Name

Doctor of Philosophy (Ph.D.)



First Committee Member

F. Daniel Armstrong - Committee Chair

Second Committee Member

Kristin M. Lindahl - Committee Member


A model of health-related quality of life in children perinatally infected with HlV/AIDS was tested by examining the relative contributions of factors unique to the experiences of children and families in this population to the children's overall functioning. Medical or disease-related variables studied included RNA viral load, CD4 counts, clinical symptoms, regimen complexity and adherence to treatment. Psychosocial or family context variables examined included caregiver relationship to the child, caregiver HIV status, perceived social support, and disclosure to the child and family's social network. Primary caregivers were the respondents and their reports on the Miami Pediatric Quality of Life Questionnaire (MPQOLQ) served as the primary outcome measure. The relative contributions of the aforementioned variables to variance on the MPQOLQ were determined using multiple regression analyses. Preliminary analyses revealed a significant effect for ethnicity, which was controlled in subsequent analyses. Results indicated that greater numbers of symptoms the children were experiencing was significantly associated with greater Emotional Stability on the MPQOLQ. In addition, the caregiver's HIV+ status and his/her relationship to the child were associated with the Total HRQL and Self Competence factors on the MPQOLQ, respectively. Additional exploratory analyses were conducted to explicate differences detected among ethnic groups. Directions for future research in this area are discussed.


Psychology, Behavioral; Psychology, Clinical

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