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Library support of clinical decision-making ranges from passive (traditional library collections of books and journals) to highly active (professional services, such as clinical medical librarians, LATCH, and informationists). Support of mobile computing resources and subscriptions to services, such as UpToDate and DynaMed, moves libraries toward interactive resources to aid healthcare providers in their decisions about specific patient questions. Librarians seeking to add robust clinical decision support systems should partner with clinicians and medical educators to weigh usability, ability to integrate with electronic health records and other systems, accuracy, reliability, depth of knowledge base, and improvements to process and patient outcomes, along with costs, which can be substantial.