Doctor of Philosophy (PHD)
Biochemistry and Molecular Biology (Medicine)
Date of Defense
First Committee Member
Second Committee Member
Third Committee Member
Fourth Committee Member
Fifth Committee Member
Herein are described two novel outcomes, the up-regulation of 5HTR2C cluster miRNAs and IGF2, as a result of GSK3 inhibition by an antidepressant dose of ketamine that may contribute to the behavioral responses to ketamine.
Depression; Glycogen Synthase Kinase-3; Ketamine; Hippocampus, microRNA; Insulin-Like Growth Factor 2
Grieco, Steven F., "Antidepressant and Molecular Responses to Ketamine Linked to its Inhibition of Glycogen Synthase Kinase-3 (GSK3)" (2016). Open Access Dissertations. 1737.