Doctor of Philosophy (PHD)
Human Genetics and Genomics (Medicine)
Date of Defense
First Committee Member
Second Committee Member
Third Committee Member
Eden R. Martin
Fourth Committee Member
Fifth Committee Member
Philip D. Harvey
Novel algorithm design, implementation, and optimization in histone modification ChIP-seq analysis of broad chromatin mark data is the subject of part I of this dissertation, focusing on data-driven precision medicine computational strategies for mapping ChIP-seq peaks to genomic features (and biological function) as well as coverage island analysis of low-sample size ChIP-seq experiments within individual biological replicates. Part II of this dissertation focuses on novel algorithm design, implementation, and analysis of high performance visualization techniques for histone modification ChIP-seq data using static and interactive biological gene expression heatmaps.
bioinformatics; ChIP-seq; epigenetics; heatmaps; HPC; genomics
Khomtchouk, Bohdan, "Histone Modification ChIP-seq Algorithm Engineering and High Performance Bioinformatics Graphics and Analysis Software for Computational Epigenetics" (2017). Open Access Dissertations. 1916.
Available for download on Friday, July 19, 2019