Publication Date

2018-12-07

Availability

Open access

Embargo Period

2018-12-07

Degree Type

Dissertation

Degree Name

Doctor of Philosophy (PHD)

Department

Chemistry (Arts and Sciences)

Date of Defense

2018-10-29

First Committee Member

Vaidhyanathan Ramamurthy

Second Committee Member

Francisco Raymo

Third Committee Member

Rajeev Prabhakar

Fourth Committee Member

Linda Shimizu

Abstract

Many important biological processes, such as photosynthesis and vision are fueled by light. Selective photoisomerization of cis-retinal linked to rhodopsin protein causes vision. Biochemical structures like, pockets of enzymes, interiors of chaperones and inner-space of proteins are few examples of confined space in nature. Light seems to be an ideal external control element for many chemical and biological manipulations. In this work, we used water-soluble deep cavitand “octa acid” (OA) as a nanocarriers to carry out various photo processes like, photoswitches, phototriggers and electron transfer. We used NMR techniques to understand the encapsulation and photoreaction of guest molecules with OA capsule.4 We also monitored the photochemical reaction by absorption, fluorescence, and transient absorption spectra. We explained the role of confined space of OA in controlling the ground and excited state properties of photoactive molecules.

Keywords

Host-guest chemistry, Photochemistry, photoswitches

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