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Publication Date

2018-12-08

Availability

UM campus only

Embargo Period

2020-05-31

Degree Type

Dissertation

Degree Name

Doctor of Philosophy (PHD)

Department

Biochemistry and Molecular Biology (Medicine)

Date of Defense

2018-07-11

First Committee Member

Sylvia Daunert

Second Committee Member

Sapna K. Deo

Third Committee Member

Joaquin Jimenez

Abstract

The development of technology that can be used to quickly and reliably assay a wide variety of matrices for the presence of specific small molecules has long been a high priority for scientists. These methods are valuable tools that see use in many fields, including biomedicine and environmental analysis. Although many contemporary technologies exist, their use is, for the most part, limited by their expense, required instrumentation, and long assay times. In an effort to address these limitations, many examples of biotechnology have been produced and this interest in biosensors continues. Herein, a number of projects to develop new bioanalytical techniques and refine existing methods are detailed and the use of these biosensing platforms is validated using both prepared samples and samples collected from the field.

Keywords

whole cell biosensor; environmental pollution; small molecule detection; bacteria; paper-based analytical systems

Available for download on Sunday, May 31, 2020

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