Doctor of Philosophy (PHD)
Molecular Cell and Developmental Biology (Medicine)
Date of Defense
First Committee Member
Second Committee Member
Nevis L. Fregien
Third Committee Member
Claudia de Oliveira Rodrigues
Fourth Committee Member
Ernesto Bernal Mizrachi
Glucose homeostasis is maintained and tightly regulated via production of key hormones that control the uptake and metabolism of glucose. β-cells, which secrete insulin, are the subject of autoimmune destruction in type 1 diabetes. From a developmental standpoint, Bone Morphogenetic Protein receptors (BMPRs) have a key role in multiple cell processes, including proliferation and differentiation. Targeting these receptors to identify and induce the proliferation of progenitor cells could have therapeutic applications. Previous studies have shown the conversion of the exocrine compartment of the pancreas to form insulin-producing cells. In this context, we have identified a cell residing in the pancreatic ducts that is positive for Activin Receptor Like Kinase 3 (ALK3, a BMPR) and Pancreatic Duodenal Homeobox 1 protein (PDX1) but negative for carbonic anhydrase II (CAII), which is a mature ductal marker. We hypothesize that these ALK3+/PDX1+/CAII- cells that reside in pancreatic ducts are responsive to Bone Morphogenetic Protein 7 (BMP7) stimulation. My goal is to allow for the stimulation of these cells in vivo, inducing their proliferation and later differentiation into endocrine (particularly insulin+) cells. This research will contribute towards a better understanding of regenerative processes in the pancreas.
Pancreas; Pancreatic Progenitors; Pancreatic Stem cells; BMP-7; ALK3; BMPR1A
Qadir, Mirza Muhammad Fahd, "Induction of Beta-Cell Regeneration by Activin-Like Kinase 3 Stimulation" (2019). Open Access Dissertations. 2419.
Available for download on Thursday, December 09, 2021