Publication Date




Embargo Period


Degree Name

Master of Science (MS)


Biomedical Engineering (Engineering)

Date of Defense


First Committee Member

Marco Ruggeri

Second Committee Member

Fabrice Manns

Third Committee Member

Jean-Marie Parel

Fourth Committee Member

Jorge Bohorquez


The goal of this thesis is to design and develop control electronics to integrate and synchronize a Spectral-Domain Optical Coherence Tomography (TD-OCT) system with an optical switch and an accommodation stimulus unit. The optical switch is implemented into the reference arm of the SD-OCT and is intended to change the length of the reference arm of the system after every frame-acquisition by a known distance. Combining consecutive frames into a single image can produce images with extended axial range while maintaining high axial and lateral resolution and high speed for in vivo imaging. The control unit also triggers a change in accommodation stimulus to the subject during imaging. In the implementation described, the range of the imaging device is extended to include the entire anterior segment and the retinal boundary. From these successive images, biometric measurements on the dynamic response of the eye to a step change in accommodation stimulus can be made.


Optical Coherence Tomography; Axial Range; ophthalmology; biometry; optical switch; accommodation